Left: In wild-type cells, RLF/ZFP292 support the proper function of the CoREST complex, leading to the removal of active histone marks and preventing excessive expression of differentiation-associated genes. Right: In the absence of RLF/ZFP292, CoREST complex function is impaired, resulting in an increase in active histone marks and elevated expression of differentiation-associated genes. Consequently, the undifferentiated state cannot be maintained, and cells undergo differentiation. Credit: University of Osaka

Stem cells are the original cell type from which all other cells and tissues in the body develop through a very tightly regulated process.…