Cryopreservation, the process of preserving biological tissue by cooling it to extremely low temperatures, often sounds like something out of science fiction. In reality, scientists have been studying and refining this technique for nearly a century. Progress remained slow for decades, but that began to change in 2023, when researchers at the University of Minnesota successfully transplanted a cryopreserved kidney into another rat. That milestone demonstrated that frozen organs could one day be used in human transplants.

Despite that progress, preserving larger organs remains a major hurdle. One of the biggest problems is cracking, which can occur when tissues are cooled too quickly. These fractures can damage the organ and make it unusable, making crack prevention a critical goal for advancing organ preservation and transplantation.

A team at Texas A&M University, led by Dr. Matthew Powell-Palm from the J.…