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The first early human eggs from stem cells - Conception | Advancing the Future of Fertility

Hacker News·3 months ago
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Why this matters Making viable eggs from stem cells has already been accomplished in mice. In 2016, our collaborator Katsuhiko Hayashi demonstrated that mouse skin cells can be turned into ‘induced pluripotent stem cells’ (iPSCs, which are engineered cells capable of becoming any kind of cell in the body) and then turned into usable eggs. These eggs produced healthy pups that lived normal lifespans and reproduced naturally, having healthy pups of their own. Figure 2 – Adult mice from eggs derived from pluripotent stem cells (Hikabe et al., 2016) This process, known as "in vitro gametogenesis” (IVG), has been far easier to achieve in mice than in larger animals. Still, given how dramatically impactful this technology could be, it is well worth pursuing for human application. IVG has the potential to redefine reproduction worldwide. From a simple blood draw, one could make as many healthy eggs as a family needs.  This capability could create freedom from biological and genetic limits.…

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