OUTLOOK

04 November 2026

Most Parkinson’s therapies aim to reduce the motor-control symptoms that the disease triggers. But stem-cell transplants in the brain could alter the disease at a more fundamental level.

By

Joohi Jimenez-Shahed Joohi Jimenez-Shahed studies movement disorders, neuromodulation and brain circuit therapeutics at the Icahn School of Medicine at Mount Sinai in New York City.

Big improvements in Parkinson’s disease treatment have been few and far between. The tantalizing prospect of regenerative stem-cell therapies to address this neurodegenerative condition is therefore creating considerable excitement.

Nature 659 , S5 (2026)

doi: https://doi.org/10.1038/d41586-026-03167-z

This article is part of Nature Outlook: Parkinson’s disease , a supplement produced with financial support from Aspen Neuroscience, Inc . Nature maintains full independence in all editorial decisions related to the content. About this content .

References

Kalia, L. V. & Lang, A. E.…