The cruise ship departed Ushuaia, Argentina, in April with plans to ferry 147 passengers and crew members to some of the most remote places on earth, including Antarctica. But the ship, named the MV Hondius, had its voyage cut short by a rare virus that has killed three and infected several others.

Hantaviruses are an ancient family of rodent-borne pathogens that likely caused disease in humans long before they first appeared in medical records in the 1950s. The viruses infect people via rodent waste — often through the inhalation of dust containing trace amounts of the excreta.…