Maybe the most inconsistent team in college football last year, the Louisville Cardinals take on the Ole Miss Rebels week one of the season for a neutral site matchup in Nashville, Tennessee.

The 2025 Cardinals showed all the signs of being great and making a push for the CFP. In a rocky, up-and-down conference like the ACC, Louisville was a dark horse for conference winners. Starting off 4-0, including a win versus the future G5 CFP winner James Madison, the Cardinals fell to then-ranked No. 24 Virginia Cavaliers.

Despite last week's home loss in OT to Virginia, the Cardinals headed to Miami to take on the No. 2 team in the nation at the time.…