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Betting on Ohio State-USC: Is an upset brewing in LA? - ESPN

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Pamela Maldonado Oct 28, 2026, 07:00 AM ET

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Pamela Maldonado is a sports betting analyst for ESPN.

No. 2 Ohio State visits a USC team that fell out of the rankings after losing to Wisconsin , but I wouldn't dismiss this matchup. The Trojans are 6-2, with another loss coming from Oregon . Ohio State already lost at Texas back in Week 2 and now turns to freshman QB Luke Fahey with Julian Sayin out.

The Buckeyes have spent all season among the national title favorites. Another loss would complicate that conversation. Every week brings an upset ... could this one be next?

Odds by DraftKings and subject to change.

No. 2 Ohio State -7 at USC

Saturday, 7:30 p.m., NBC

Records: Ohio State 6-1, 2-1 vs. AP Top 25; USC 6-2, 0-1 vs.…

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