Synchrotron X-rays uncover hidden protein binding sites, enabling two new functions

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Synchrotron X-rays uncover hidden protein binding sites, enabling two new functions

phys.org·Carol Tseng·6 months ago

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Starting with the designed protein apixaban-binding helical bundle (ABLE, center), researchers designed two new proteins: Kemp eliminase ABLE (KABLE, left), an enzyme with record activity, and fluorescent ABLE (FABLE, right), a compound that acts as a "light switch." Credit: Greg Stewart/SLAC National Accelerator Laboratory

Using bright X-rays from the Department of Energy's SLAC National Accelerator Laboratory and Lawrence Berkeley National Laboratory (Berkeley Lab), researchers pioneered an innovative approach to designing proteins with targeted functions.…

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Synchrotron X-rays uncover hidden protein binding sites, enabling two new functions