A Long Island Rail Road strike could strand nearly 300,000 commuters starting this weekend as five labor unions and MTA leaders are at odds over wage increases for the union workers.

The looming work stoppage could start as early as 12:01 a.m. Saturday as MTA chief Janno Lieber and Gov. Kathy Hochul this week simply advised riders to work from home if workers walk off the job.

“I want to make sure commuters are not inconvenienced and if they have that option [to work from home], they may have to exercise it,” Hochul said Wednesday at an unrelated event at Jones Beach.

A Long Island Rail Road train at Penn Station.…