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College football predictions: Underdog is best play in Duke vs Virginia

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October 22, 2026 - 4:40 pm

Duke vs. Virginia is the spotlight game for me, but I also have a bet on Air Force vs. Wyoming.

4 p.m. Friday, ESPN

Both teams are licking their wounds heading into this one, though Duke’s run a little deeper.

Teams never enter a game expecting to lose, but Virginia faced a tall task against SMU. The Blue Devils, meanwhile, lost at home to North Carolina, 24-20, in their rivalry game, dropping their second straight ACC contest.

Conference titles and a CFP berth are always goals entering the season, but so is beating your archrival.

Speaking of rivals, this is a revenge game for the Cavaliers, who lost to Duke in overtime in the ACC Championship Game and missed out on the CFP. You know Tony Elliott hasn’t let his team forget that, even though this year’s roster looks much different.

Manny Diaz has proven to be a good coach in Durham, and he should have his team ready to get back in the win column.…

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