Pope Leo XIV waves after meeting with Uruguay's President Yamandu Orsi at Plaza Independencia in Montevideo, Uruguay, Friday, Nov. 6, 2026. Matilde Campodonico

/AP

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Matilde Campodonico

/AP

MONTEVIDEO, Uruguay — Pope Leo XIV has arrived in South America for a 12-day, three-country journey that will be his longest and most far-reaching trip yet, and his first major overseas visit since undergoing lung cancer surgery.

Along the way Leo will take 12 flights, including two helicopter rides, give 36 speeches and visit 10 cities including Cusco, Peru, which sits more than 11,000 feet above sea level. Even the heartiest of travelers can experience altitude sickness there and may require supplemental oxygen.

Last month, Leo underwent surgery to remove the lower lobe of his right lung. Vatican officials say he has completed his two-week recovery period and requires no further treatment.

The Vatican's new communications chief Maria Montserrat Alvarado said the pontiff was eager to begin his journey.…