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In Vivo CRISPR Base Editing of ANGPTL3 for Durable Lipid Lowering

#nature#science#orcid#medicine#angptl3
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Published: 06 November 2026

Jamie E. DeNizio 1 ,

Alexandra C. Chadwick 1 ,

Anne Marie Mazzola 1 ,

Maxwell P. Brown 1 ,

Shashank Mishra 1 ,

Manashree Damle 1 ,

Yuri Matsumoto 1 ,

Victoria Neang 1 ,

Ryan Garrity 1 ,

Manini Mantri 1 ,

Joy Oshoname Olorife 1 ,

Hui-Ting Hsu 1 ,

Vian Peshdary 1 ,

Estela Shabani 1 ,

John D. Ganey 1 ,

Ryan Santos 1 ,

Anthony Federico 1 ,

Sara P. Garcia 1 ,

Pengying Hao 1 ,

Yue Wu 1 ,

Zachary Glass 1 ,

Lisa N. Kasiewicz 1 ,

Caroline Summers 1 ,

Athul Sanjeev 1 ,

Kui Wang 1 ,

Steven D. Briscoe 1 ,

Robert S. Rosenson ORCID: orcid.org/0000-0002-5599-0633 2 ,

Christopher J. Cheng ORCID: orcid.org/0009-0008-8092-5199 1 ,

Ellen Rohde 1 ,

Joseph Biedenkapp 1 ,

Victor Farutin 1 ,

Andrew M. Bellinger 1 , 3 ,

Kiran Musunuru ORCID: orcid.org/0000-0003-3298-0368 4 , 5 , 6 ,

Sekar Kathiresan 1 ,

Troy Lister 1 ,

Kallanthottathil G. Rajeev 1 ,

Richard G. Lee 1 &

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Amit V.…

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