Christian McCaffrey continues to dominate fantasy football with his explosive performances, but now an injury has left the running back questionable to return against the Falcons.

The 49ers are already without several key receivers, including Mike Evans and Deebo Samuel, but wide receiver Christian Kirk has been activated from IR.

Without McCaffrey leading the running backs, who gets the workload for the 6-0 49ers?

Fantasy Football Impact

RB Christian McCaffrey, San Francisco 49ers

McCaffrey has remained the starting running back for the 49ers, and he has been a key man for fantasy managers this season.

The running back is averaging 20.3 fantasy points per game, making him a must-start back for managers.

Injuries have hindered McCaffrey's previous seasons, and a thigh injury is the latest injury to the 10th year running back.

#49ers @SutterHealth Injury Update: Christian McCaffrey is questionable to return (thigh).

— San Francisco 49ers (@49ers) October 25, 2026

RB Kaelon Black, San Francisco…