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AI agent used to perform controversial brain surgery on a mouse, Anthropic Sonnet-controlled motorized surgery rig — Opus 5.5 refused to conduct biological experiment, Sonnet given free rein to treat epilepsy with a range of gene therapy vectors after

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Exin Therapeutics, a biotech startup focusing on next-generation neurotherapeutics, claims it has successfully conducted brain surgery on a mouse using an AI agent. Its co-founder and CEO, Gabriel Ocana-Santero, shared the entire procedure on X, showing how the AI agent chose the gene therapy vector and dosage and the brain region where it would be applied. The AI agent also drove the robotic arms that injected the medication into the mouse’s brain. Thankfully, the operation seems to have been a success, with the mouse recovering well and recorded moving around in its enclosure.

Last night an AI agent performed brain surgery on a mouse. We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures. It picked the drug. It picked the brain region. It derived the coordinates from three papers.…

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