People walk past a sign for Novo Nordisk’s annual general meeting at the entrance to the venue in Copenhagen, Denmark, March 26, 2026.

Tom Little | Reuters

Novo Nordisk hiked annual profit guidance on Wednesday, as the pharmaceutical group revealed its blockbuster weight-loss drugs performed better than expected in the first three months of the year.

The Danish drugmaker said first-quarter sales jumped 32% on a constant currency basis to reach 96.8 billion Danish kroner ($15.2 billion), soaring above an analyst consensus of 71.3 billion kroner compiled by FactSet.…