Polymarket claims its headquarters is on the 21st floor of the Oceania Business Plaza. So do more than a dozen other crypto companies. But the address leads to a law firm. Eliana Morales Gil hide caption

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Eliana Morales Gil

PANAMA CITY — On the 21st floor of a gleaming skyscraper in the heart of the upscale Punta Pacifica neighborhood here is the official corporate office of Polymarket, the wildly popular prediction market site that has flourished in President Trump's second term.

Polymarket, which is worth an estimated $15 billion, moved to its Panama base following scrutiny from American regulators.…