The San Francisco 49ers are entering the 2026 season with clear Super Bowl expectations, but the same issue that held them back last year could once again play a major role. Injuries remain the biggest concern surrounding the team.

Will injuries derail the San Francisco 49ers again in 2026?

Brad Gagnon of Bleacher Report outlined nightmare scenarios for every team, and for the 49ers, the focus was straightforward.

“Quite simply, injury luck even remotely resembling what they encountered in 2025 would be a terror for the Niners.”

Brad Gagnon

While injuries can be attributed to bad luck, there are also factors that suggest this could remain an ongoing issue for the 49ers who have had this run of bad luck too often. The 49ers are relying on several key players who have dealt with injuries in the past.…