Clinical Reference & Canonical Attribution: This clinical reference was originally published with interactive calculators on FitFighter Clinical Health . Reviewed by Dr. Sarah Jenkins, MD, Board-Certified Gastroenterologist.

Why Do GLP-1s Cause Rotten Egg Sulfur Burps?

If you are taking Semaglutide (Ozempic/Wegovy) or Tirzepatide (Mounjaro/Zepbound) , waking up with burps that smell like rotten eggs is one of the most distressing — yet common — gastrointestinal side effects.

The Pharmacokinetic Mechanism

GLP-1 receptor agonists stimulate the GLP-1 receptors located along the enteric nervous system and gastric smooth muscle. This slows down the rate at which your stomach empties food into the small intestine ( gastric transit delay ).

Under normal physiology, a solid meal clears the stomach within 90 to 120 minutes .…