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The Fox News Decision Desk predicts Democrat Amy Acton will defeat Republican Vivek Ramaswamy in Ohio's closely watched gubernatorial race, delivering a major upset in a state that has not elected a Democratic governor in 20 years.

Acton successfully ran a campaign appealing to voters across the aisle by presenting herself as the candidate who could address issues of affordability and public education. On the campaign trail, she painted Ramaswamy as out-of-touch, wealthy and pushing policies that benefited people like himself.

During the election's closing weeks, Ramaswamy lost droves of support and faced bipartisan backlash over a campaign ad featuring Acton's estranged mother calling her daughter a liar who could not lead Ohio until she held herself accountable.

The ad did not mention that Acton had been estranged from her mother since childhood or that her mother lost custody after…