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Masked mitochondria slip into cells to treat disease in mice

www.nature.com·Chen, Edward·7 months ago
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Transplantation technique lengthened survival in animals with an often-fatal mitochondrial disease.

A well-fitted ‘disguise’ allows transplanted mitochondria to slip into cells whose own mitochondria are defective, scientists reported on 18 March in Cell1. Administration of these cloaked mitochondria prolonged the life of mice with a deadly disease caused by abnormal mitochondria.

References

  1. Du, S. et al. Cell https://doi.org/10.1016/j.cell.2026.02.023 (2026).

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  2. Lin, R. et al. Nature 629, 660–668 (2024).

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  3. Jackson-Lewis, V. & Przedborski, S. Nature Protoc. 2, 141–151 (2007).

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