September 8, 2026 Science

How predicting the molecular impact of every possible single-letter DNA variant in the human genome will help accelerate our understanding of biology.

Today, we are introducing AlphaGenome Atlas: a platform ( detailed in our paper ) containing predictions for the effects of 9 billion single-nucleotide variants — every single-letter change possible — in the human genome. It is the most comprehensive catalogue of how genetic mutations affect molecular biology, and it is available for academic research through an intuitive and free-to-use website portal .

DNA is the language of life. Mastering it is a grand challenge that could transform our ability to understand biology and treat disease. But progress has been limited by a fundamental problem: interpreting how genetic variations impact biology at a molecular level.…