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In Vivo CRISPR Base Editing of ANGPTL3 for Durable Lipid Lowering

#nature#science#orcid#medicine#angptl3

Circulating concentrations of low-density lipoprotein cholesterol (LDL-C) and triglyceride-rich lipoproteins are leading risk factors for atherosclerotic cardiovascular disease1.…

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Lipid nanoparticles engineered to target therapeutic RNA to the pancreas

#nature#lipid#englishlanguage

The clinical use of lipid nanoparticles (LNPs) for drug delivery is currently limited by their tendency to accumulate in the liver.

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