TL;DR (Quick Answer)
I actually ran Qwen3.6-35B-A3B — a 35B-parameter mixture-of-experts model (only 3B active per token) — on a pair of 8-year-old GTX 1080 Ti cards (22 GB combined). Real, measured numbers:
Generation speed: ~20 tokens/sec on 2× 1080 Ti (IQ4_XS quant), stable across runs (19.4 / 21.4 / 20.0).
Single GPU: ~16.8 tok/s. So the second 1080 Ti buys ~20% more throughput — not 2×. Why: the MoE expert weights stay memory-mapped in CPU RAM either way; the second GPU just lets more of the model live in fast VRAM.
It only "fits" because of the MoE + CPU-mmap trick. ~13 GB of the model sits on the two GPUs; ~18 GB of expert weights are mmap'd from CPU RAM, and only the active 3B runs each token.
Quant matters for 22 GB: the default qwen3.6:35b-a3b tag is 23.9 GB and spills to CPU .…