Pan, X. & Kortemme, T. Recent advances in de novo protein design: principles, methods, and applications. J. Biol. Chem. 296 , 100558 (2021).

Article CAS PubMed PubMed Central Google Scholar

Woolfson, D. N. A brief history of de novo protein design: minimal, rational, and computational. J. Mol. Biol. 433 , 167160 (2021).

Article CAS PubMed Google Scholar

Marchand, A., Van Hall-Beauvais, A. K. & Correia, B. E. Computational design of novel protein-protein interactions—an overview on methodological approaches and applications. Curr. Opin. Struct. Biol. 74 , 102370 (2022).

Article CAS PubMed Google Scholar

Korendovych, I. V. & DeGrado, W. F. De novo protein design, a retrospective. Q. Rev. Biophys. 53 , e3 (2020).

Article CAS PubMed PubMed Central Google Scholar

Khakzad, H. et al. A new age in protein design empowered by deep learning. Cell Syst. 14 , 925–939 (2023).

Article CAS PubMed Google Scholar

Arnold, F. H. Directed evolution: bringing new chemistry to life. Angew. Chem. Int. Ed.…